CNS Member


Adrián Ponce-Alvarez
I am broadly interested in general principles underlying brain function. My current research concerns the study of neural networks, both at the microcircuit and at large-scale level. In particular, I am interested in 1) how network statistics are related to structure and efficient information processing, and 2) how collective behaviour emerges in neural networks. My approach uses stochastic dynamical systems, information theory, statistical physics, statistical models.

Postdoc (Juan de la Cierva fellowship)

(*: equal contribution)
[1] Gilson M, Moreno-Bote R, Ponce-Alvarez A, Ritter P, Deco G (2016) Estimation of Directed Effective Connectivity from fMRI Functional Connectivity Hints at Asymmetries of Cortical Connectome. PLoS Comput Biol. e1004762. doi: 10.1371/journal.pcbi.1004762
[2] Ponce-Alvarez A, He B, Deco G (2016) Task-Driven Activity Reduces the Cortical Activity Space of the Brain: Experiment and Whole-Brain Modeling. PLoS Comput Biol. e1004445. doi: 10.1371/journal.pcbi.1004445.
[3] Ponce-Alvarez A, Deco G, Hagmann P, Romani GL, Mantini D, Corbetta M (2015) Resting-state temporal synchronization networks emerge from connectivity topology and heterogeneity. PLoS Comput Biol. e1004100. doi: 10.1371/journal.pcbi.1004100.
[4] Deco G*, Ponce-Alvarez A*, Hagmann P, Romani GL, Mantini D, Corbetta M (2014) How local excitation-inhibition ratio impacts the whole brain dynamics. J Neurosci. 34(23):7886-98. doi: 10.1523/JNEUROSCI.5068-13.2014
[5] Ponce-Alvarez A*, Thiele A*, Albright TD, Stoner GR, Deco G (2013) Stimulus-dependent variability and noise correlations in cortical MT neurons. Proc Natl Acad Sci U S A. 110(32):13162-7. doi: 10.1073/pnas.1300098110
[6] Deco G*, Ponce-Alvarez A*, Mantini D, Romani GL, Hagmann P, Corbetta M (2013) Resting-state functional connectivity emerges from structurally and dynamically shaped slow linear fluctuations. J Neurosci. 33(27):11239-52. doi: 10.1523/JNEUROSCI.1091-13.2013
[7] Confais J, Kilavik BE, Ponce-Alvarez A, Riehle A (2012) On the anticipatory precue activity in motor cortex. J Neurosci. 32(44):15359-68. doi: 10.1523/JNEUROSCI.1768-12.2012
[8] Ponce-Alvarez A, Nácher V, Luna R, Riehle A, Romo R (2012) Dynamics of cortical neuronal ensembles transit from decision making to storage for later report. J Neurosci. 32(35):11956-69. doi: 10.1523/JNEUROSCI.6176-11.2012
[9] Kilavik BE, Ponce-Alvarez A, Trachel R, Confais J, Takerkart S, Riehle A (2012) Context-related frequency modulations of macaque motor cortical LFP beta oscillations. Cereb Cortex. 22(9):2148-59. doi: 10.1093/cercor/bhr299
[10] Kilavik BE, Confais J, Ponce-Alvarez A, Diesmann M, Riehle A (2010) Evoked potentials in motor cortical local field potentials reflect task timing and behavioral performance. J Neurophysiol. 104(5):2338-51. doi: 10.1152/jn.00250.2010
[11] Ponce-Alvarez A, Kilavik BE, Riehle A (2010) Comparison of local measures of spike time irregularity and relating variability to firing rate in motor cortical neurons. J Comput Neurosci. 29(1-2):351-65. doi: 10.1007/s10827-009-0158-2
[12] Kilavik BE, Roux S, Ponce-Alvarez A, Confais J, Grün S, Riehle A (2009) Long-term modifications in motor cortical dynamics induced by intensive practice. J Neurosci. 29(40):12653-63. doi: 10.1523/JNEUROSCI.1554-09.2009
[13] Johnson LR, Hou M, Ponce-Alvarez A, Gribelyuk L, Alphs H, Albert Jr L, Brown BL, LeDoux J and Doyere V (2008). A recurrent network in the lateral amygdala: a mechanism for coincidence detection. Front. Neural Circuits 2:3. doi: 10.3389/neuro.04.003.2008

Book chapters
Ponce-Alvarez A. and Deco G (2015) The Emergence of Spontaneous and Evoked Functional Connectivity in a Large-Scale Model of the Brain in Arthur Toga (eds), Brain Mapping: An Encyclopedic Reference, Academic Press: Elsevier, vol. 1, pp 571-579.